In patients with premalignant lesions such as lichen planus, oral leukoplakia, and oral submucosal fibrosis, elevated concentrations of IL-6 and IL-8 can be found in the saliva and serum, and furthermore, their high levels in biological fluids are correlated with reduced survival and increased relapse rate in OSCC, if previously diagnosed [58]. The gene discussed is CXCL8; the disease is oral submucous fibrosis.