Salivary levels of Interleukin-1α (IL-1 α), IL-6, IL-8, Vascular-Endothelial Growth Factor- α (VEGF- α) and Tumor Necrosis Factor- α (TNF- α) can support analysis of the progression of premalignant lesions of the tongue and could be used for cancer screening and early diagnosis [23]. The gene discussed is TNF; the disease is cancer.