Endothelin-1 represents a potential biomarker for the development of OSCC in patients with oral lichen planus and IL-8, IL-1β, glycoprotein M2BP (Mac-2 binding protein), CD59, myeloid protein 14 (MRP14) and catalase as salivary biomarkers of oral cancer [44]. This evidence concerns the gene EDN1 and oral lichen planus.