The alternative RAAS arm typically is considered beneficial in the setting of the RAAS‐activated state of heart disease because it indicates higher concentrations of angiotensin 1‐7 (which promote vasodilatation, natriuresis, diuresis, and anti‐inflammatory effects) and lower concentrations of angiotensin II and other classical metabolites (which promote vasoconstriction, sodium and water retention, and inflammation). This evidence concerns the gene AGT and heart disorder.