MAPT and Alzheimer disease: While CSF levels of NPTX2/T-tau were not correlated with GM-CBF in CU individuals (Supplementary Table 10), a positive association was observed between NPTX2/T-tau and GM-CBF in the AD continuum for lateral parietal (β = 0.0517, p(FDR) = 0.0081), lateral temporal (β = 0.0553, p(FDR) = 0.0081), superior lateral occipital (β = 0.0899, p(FDR) = 0.0016) and middle frontal (β = 0.0815, p(FDR) = 0.0003) ROIs, see Supplementary Figure 14.