Anwuligan inhibits the growth and metastasis of NSCLC cells by upregulating the expression of let‐7c‐3p, which can bind to the 3′‐untranslated region (UTR) of PIK3CA and downregulate the PI3K/AKT/mTOR signalling pathway. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.