Pathway enrichment analysis performed on the lists of DEGs generated from the comparisons of BE-GICs versus nBE-GICs identified a deregulation of immune-related pathways – TGF-beta signalling and interferon-gamma signalling (Figure 3H), raising the possibility of differences in the tumour microenvironment of these glioblastomas. The gene discussed is IFNG; the disease is glioblastoma.