CMKLR1 and neoplasm: In scRNAseq data from Pombo Antunes et al., 2021, and Neftel et al., 2019, the receptor CMKLR1 is expressed in tumour-associated macrophages (TAMs) from newly diagnosed GBMs (Figure 5C, D), particularly in non-hypoxic TAMs (such as SEPP1-hi TAMs) as compared to hypoxic TAMs in recurrent glioblastomas (Figure 5E, F).