A hypo-methylation bias has been previously found also in the paediatric H3 G34 mutant glioma subgroup (Sturm, 2012), where mutations in the histone H3 variant H3.3 (H3F3A) block SETD2 binding, leading to loss of H3K36 methylation, which in turn is linked to DNA methylation (Rose and Klose, 2014). Here, SETD2 is linked to central nervous system cancer.