SH2D3A and COVID-19: Altogether, the high structural similarity across different α- and β-CoVs from different organisms, the fact that Nsp1 has no homologues outside of the CoVs, as well as its crucial role in mediating immune evasion, make Nsp1 a valuable target for developing antiviral drugs, not only for the ongoing COVID-19 pandemic but also to prevent future pandemic outbreaks caused by new variants.