This effect could be explained by the cytokine‐ or chemokine‐dependent cytotoxicity that the secreted CXCL10, IL‐12, and TNFa in QTPlus‐AM21‐stimulated macrophages could inhibit MC38 cancer cell growth in vitro.[60] In the MC38 syngeneic mouse model, 3 mg kg−1 of QTPlus‐AM21 showed significant antitumor activity (Figure 8). Here, TNF is linked to cancer.