Bintrafusp alfa, a bifunctional fusion protein leveling TGF‐β and PD‐L1 blockade overcomes an immunosuppressive tumor environment in murine models by increasing TIL expression and infiltration, stimulation of interferon genes (STING), decreasing PMN‐MDSCs and leveraging TGF‐β trap to PD‐L1 blockade. The gene discussed is CD274; the disease is neoplasm.