Chen et al have established preclinical studies in murine models with 93‐O17S‐F is a lipidoidal‐based nanoparticles that potentiates in‐situ vaccine strategy by releasing tumor antigens TAAs to stimulate the cGAS‐STING pathway by mediating through interferon exposed to prior administration with doxorubicin. The gene discussed is STING1; the disease is neoplasm.