Tumor cells affect upregulation of cell adhesion molecules, TNF family ligands and major histocompatibility complex class I and II which in turn allow circulating DCs to transfer the TAAs to nodal regions and present to CD4 and CD8 T lymphocytes causing their activation via interaction of T‐cell receptors with peptide/MHC complexes on APCs.75 Here, CD4 is linked to neoplasm.