Interestingly, inhibition of the YTHDC1 expression in the SCC9 and HN4 cell lines resulted in a reduction in the expression of SOX2, BMI1, OCT4, and NANOG (Figures 4(d) and 4(e)), indicating a significant decrease in the stemness of HNSCC cells. This evidence concerns the gene SOX2 and head and neck squamous cell carcinoma.