CD8A and tuberculosis: Computer-based modeling efforts have highlighted that critical roles for multifunctional CD8+ T cells are barriers to the dissemination of Mtb. B cells are also important contributors to anti-TB immune responses, functioning within germinal centers to produce antibodies capable of modulating innate and adaptive immunity, enhancing the presentation of antigens to T cells, and producing cytokines that can support ongoing T cell responses [21, 22].