TGFB1 and hepatocellular carcinoma: Based on the above results, instead of PFD alone, we propose to prepare PEGylated PFD/PFP/liposome nanoparticles (PPL NPs) combined with LIFU-triggered UTMD to inhibit the activity of a-HSCs and reduce the expression of TGF-β, which in turn inhibits the EMT of HCC.