Crosslinking of multiple antisense strands in line via reducible dithio-bis-maleimidoethane, followed by hybridization of the sense strand with anti-mucin 1 (MUC1) aptamer and intercalating doxorubicin (Dox) to the stem of the aptamer showed specific targeting to human breast cancer MCF-7 cells, silencing of antiapoptotic BCL2 mRNA and inhibition of cell proliferation[126]. This evidence concerns the gene MUC1 and breast carcinoma.