Moreover, the combination of the serotonin 5-HT2A/C agonist DOI with specific 5-HT2A antagonist Kentaserin and M100907, as well as, the specific 5-HT2C antagonist SB242084, highlighted the specific contribution of serotonin 5-HT2A receptors in the inhibition of the compulsive drinking behavior in HD rats on SIP. This evidence concerns the gene HTR2A and Huntington disease.