CD38 and B-cell chronic lymphocytic leukemia: Parameters such as age, the absolute count of hematological changes, including (WBC, Lymphocyte, Hb, Hct, Plt), CD38 expression in CLL phenotype cells and mean CD38+ expression (≥30%) in cells with aCLL phenotype were examined by mutations related to the NOTCH1, exon 34, PEST domain and the SF3B1, exons 14–16, HEAT domain repeats 3–6 (Table 2).