Parameters such as age, the absolute count of hematological changes, including (WBC, Lymphocyte, Hb, Hct, Plt), CD38 expression in CLL phenotype cells and mean CD38+ expression (≥30%) in cells with aCLL phenotype were examined by mutations related to the NOTCH1, exon 34, PEST domain and the SF3B1, exons 14–16, HEAT domain repeats 3–6 (Table 2). This evidence concerns the gene SF3B1 and B-cell chronic lymphocytic leukemia.