S100A8 and Renal insufficiency: In people, urinary calprotectin (S100A8/A9) is increased in high-grade UC (the human counterpart of the invariably present muscle-invasive form of canine UC) compared to low-grade UC or absence of UC, provided the exclusion of renal failure and pyuria [63] because calprotectin loses specificity as a tumor marker even with sterile leukocyturia (pyuria) [65].