HK2 and sarcoma: Nevertheless, the proglycolytic role of NF-κBp65 in some studies of different cancer cells has shown consistent findings, e.g., inhibition of the classical NF-κB pathway results in downregulation of glycolytic enzymes, particularly hexokinase 2 (HK2), and is subsequently accompanied by decreased glycolysis in sarcoma cells [25] and primary central nervous system lymphoma [26].