When S-Klotho levels are high, men are at lower risk of hyperuricemia than women [male: Q4 vs Q1, OR(95%CI): 0.67 (0.56, 0.81), P < 0.001; female: Q4 vs Q1 (95%CI):0.72 (0.58, 0.88), P < 0.001] (Table 5). The gene discussed is KL; the disease is hyperuricemia.