EGFR and cancer: Similar to previous studies on EGFR inhibitors [20], serum LDH levels were elevated after radiotherapy in a fraction of NPC subjects with high GSDME expression who showed nasopharyngoscopy-verified (Fig. 4I, patient I & Supplementary Figure S3A, patients V, VI, who received radiotherapy alone) or MR-verified (Fig. 4J, patient III & Supplementary Figure S3B, patient VIII, who received chemoradiotherapy) rapid cancer regression, representing radiosensitive cases.