However, the serum LDH concentration of patients with low GSDME expression showed no apparent upward trend after radiotherapy, and nasopharyngoscopy assessment showed a slow regression of the tumor, representing radioresistance (Fig. 4I, patient II & Supplementary Figure S3A, patient VII, who received radiotherapy alone; Fig. 4J, patient IV & Supplementary Figure S3B, patients IX, X, who received chemoradiotherapy). Here, GSDME is linked to neoplasm.