Although a few investigations have demonstrated the association between SLIT2 promoter methylation and SLIT2 expression in some types of solid tumors [23], our recent study revealed that SLIT2 promoter methylation was correlated with the expression of SLIT2-embedded ncRNAs SLIT2-IT1/miR-218 but not with SLIT2 in AML [12]. This evidence concerns the gene SLIT2 and acute myeloid leukemia.