Of note, three of the four genes that were significantly regulated in all investigated conditions showed lessened induction upon concomitant infection and Smh1 expression (IL-1β, GLIS3, and MIR3142HG), while down-regulation of the fourth factor (RGS4) is accentuated by Smh1 expression (Figure 2(d)). Here, MIR3142HG is linked to infection.