By affecting this system, exercise training can attenuate the susceptibility of individuals to detrimental functions of COVID-19 infection or mitigate the severity of disease by the following additional strategies: (1) mitigated severity of comorbidities [247] and as a result reduced COVID-19-induced mortality rates [410, 411] and (2) warded off the diminishing effects of COVID-19 on ACE2 via increasing ACE2 activity and its concentration [412], although the positive or negative effects of increasing ACE2 should be investigated. The gene discussed is ACE2; the disease is COVID-19.