Evidence for the AD association of rare variants in ADAM10 has remained suggestive until now: two rare missense variants in ADAM10 were reported before to incompletely segregate with LOAD in a few families14 (these variants did not associate with AD in our study; Supplementary Data) and a nonsense variant in the ADAM10 gene segregated with AD but in a small pedigree15. The gene discussed is ADAM10; the disease is Alzheimer disease.