Screening of these upregulated genes for classified cancer-associated genes according to the COSMIC Cancer Gene Census (CGC), the OncoKB and the Network of Cancer Genes databases (NCG 7.0) revealed the receptor tyrosine kinase PDGFRA (platelet-derived growth factor alpha) as the most upregulated oncogene in IDH1-mut AML (Fig. 1A). The gene discussed is PDGFRA; the disease is acute myeloid leukemia.