KRAS and neoplasm: To identify clonal differences in metabolism, we profiled a series of clonal cell lines derived from a single Kras+/G12D; Trp53+/R172H; Pdx1-Cre (KPC) mouse tumor (Fig. 1a and Supplemental Table 1) by liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based metabolomics.