Although only a fraction of the CD45+ cells have a B-cell immunophenotype28, clear enrichment of RUNX1 and ETV6-RUNX1 was observed across the peaks identified in BCP-ALL (Supplementary Figs. 1c and 2d) and the combined RUNX1 and ETV6-RUNX1 peaks from the CD45+ cells were enriched for RUNX and ETS motifs (Supplementary Fig. 2e), indicating overlap between the regulatory programs in these experimental systems. This evidence concerns the gene ETV6 and acute lymphoblastic leukemia.