Of the three members of the RUNX family, RUNX1 is dominant in B-ALL, with RUNX2/3 very low at the transcript level (FPKM<1, Supplementary Fig. 5f) and not substantially increased following RUNX1 knockdown (Supplementary Fig. 5g). This evidence concerns the gene RUNX1 and precursor B-cell acute lymphoblastic leukemia.