Although no individual SNP reached genome-wide significance, subsequent gene-based tests of association identified four genes significantly associated with cannabis initiation: NCAM1, CADM2, SCOC, and KCNT2. In a more recent ICC report [75], where the meta-analytic sample for cannabis initiation was increased to ~184,000 individuals, eight independent genome-wide significant SNPs in six regions were identified, as well as 35 significant genes in a gene-based tests of association. The gene discussed is CADM2; the disease is intrahepatic cholangiocarcinoma.