GRAMD1B and cryptococcosis: The rapid, dose-dependent fungicidal activity of LAmB has been established in preclinical studies of invasive candidiasis,33 mucormycosis,34 histoplasmosis35 and blastomycosis35 in addition to cryptococcosis.36 From the present PK model, it is clear that plasma concentrations fall to negligible levels 48–72 h after a single dose of 10 mg/kg of AmBisome.