CD40LG and infection: Our findings mirror our recent screening of a separate cohort of 100 patients with GBS, where we report a similarly heterogeneous reactivity of their IgG and IgM antibodies to nerve-related antigens.20 The narrow definition of the present GBS cohort, in which all patients associated with the same infectious insult, suggests that the heterogeneity of the humoral immune responses in GBS may be a core feature of the disease and not necessarily due to the heterogeneity of the patient cohorts or prodromal infections.