In 2006 BRIP1 was reported as a low-penetrance BC gene.19 However, subsequent larger and more comprehensive studies have suggested that there is not a significant association with BC predisposition.18 20 21 The recent BCAC study did not identify an association between truncating variants in BRIP1 and BC risk (OR=1.11, 95% CI 0.80 to 1.53; p=0.54),8 and it is now widely considered that BRIP1 is not a BC predisposition gene. The gene discussed is BRIP1; the disease is breast cancer.