Detection rates in a large population-based study of patients with BC were 274/47 522 (0.58%) for PALB2, 54/47 522 (0.11%) for RAD51C, 51/47 522 (0.11%) for RAD51D and 86/47 522 (0.18%) for BRIP1, compared with 515/48 826 (1.05%) for BRCA1 and 754/48 826 (1.54%) for BRCA2. This evidence concerns the gene RAD51C and breast cancer.