GPV in both RAD51C and RAD51D has been identified in BC and OC families.16 17 For both genes, the association appears to be strongest with triple negative or ER (estrogen receptor) -negative BC.8 18 The largest study to date16 analysed data from 125 families with GPV in RAD51C and 60 families with RAD51D. Here, ESR1 is linked to breast cancer.