Treatment with this group of antipsychotic drugs has been associated with motor and cognitive deficits in patients.36 37 In contrast, second-generation antipsychotics are reported to have fewer extrapyramidal side effects,38 with these drugs also acting as an antagonist at the serotonin 5HT2A receptor, in addition to D2 dopamine receptors. This evidence concerns the gene DRD2 and Cognitive impairment.