Nonsense mutations in CD36 are also being associated with insulin resistance, familial type 2 diabetes, CD36-mediated ER stress and inflammatory signaling (JNK, NF-κB) implicated in diet-induced obesity and reduced insulin sensitivity (Furuhashi et al, 2003; Lepretre et al, 2004; Karunakaran et al, 2021). Here, CD36 is linked to obesity due to melanocortin 4 receptor deficiency.