As DKK1 is a natural antagonist of the Wnt signaling (Gonzalez-Sancho et al, 2005; Menezes et al, 2012) and the Wnt pathway is reportedly involved in metabolic syndromes (Ackers & Malgor, 2018; Abou Ziki & Mani, 2019) such as NAFLD (Liu et al, 2011; Wang et al, 2015), the expressions of key genes in Wnt signaling were examined in DKK1 knockout HepG2 cells treated with FFA. Here, DKK1 is linked to metabolic syndrome.