Symptoms of hyperandrogenism and particularly virilizing symptoms (including, eg, clitoromegaly, deepening of the voice, and breast atrophy besides severe hirsutism and possibly androgenic alopecia) in a postmenopausal woman should be evaluated by endocrine screening, preferably serum FSH, LH, testosterone, SHBG, A4, DHEAS, estradiol, 17-OHP, and inhibin B (Table 4). This evidence concerns the gene SHBG and hyperandrogenism.