Serum analyses of FSH, LH, testosterone, SHBG, A4, DHEAS, estradiol, 17-OHP, and inhibin BHOMA index or HbA1C as marker for insulin resistance can be consideredACTH stimulation test to rule out NC CAH24-hour urinary free cortisol and dexamethasone test to rule out Cushing's syndrome. The gene discussed is SHBG; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.