PLAT and stroke disorder: Thrombolytics are not a benign drug; prior studies on tPA in strokes have shown risks including symptomatic intracranial hemorrhage, major systemic hemorrhage, and angioedema in 6%, 2%, and 5% of patients, respectively.25 Recent studies on IV and intra-arterial tPA in frostbite have shown complication (rates between 2.3–10 % (compartment syndrome, bleeding requiring transfusion, and hematoma).26,27 Thus, judicious administration of thrombolytics is an important decision that should be made with appropriate clinical information.