Thrombolytics are not a benign drug; prior studies on tPA in strokes have shown risks including symptomatic intracranial hemorrhage, major systemic hemorrhage, and angioedema in 6%, 2%, and 5% of patients, respectively.25 Recent studies on IV and intra-arterial tPA in frostbite have shown complication (rates between 2.3–10 % (compartment syndrome, bleeding requiring transfusion, and hematoma).26,27 Thus, judicious administration of thrombolytics is an important decision that should be made with appropriate clinical information. This evidence concerns the gene PLAT and angioedema.