When divided into two groups based on greasy food preference, the Trp64Arg had higher preference for HF foods (vs. Trp64Trp), suggesting that Arg substitution might genetically enhance HF preference. Understanding the relationship between ADRB3 Trp64Arg substitution and fat preference could be valuable for obesity prevention. This evidence concerns the gene ADRB3 and obesity due to melanocortin 4 receptor deficiency.