In our study cohort, SLE patients of non‐European ancestry had higher rates of hypocomplementemia (57% versus 43.0%; chi‐square test = 4.0, P = 0.045), higher total IgG levels (16.2 gm/liter versus 10.9 gm/liter; t‐test = 4.8, P < 0.000), and higher seropositivity for U1 RNP/Sm antibodies (50% versus 12%; chi‐square test = 28.6, P < 0.000), Ro 60 antibodies (45% versus 29%; chi‐square test = 4.2, P = 0.040), and anti‐dsDNA antibodies (68% versus 46%; chi‐square test = 7.3, P = 0.006). The gene discussed is CALR; the disease is systemic lupus erythematosus.