Although the MyBP-C paralogs have yet to be fully described in aging skeletal muscles, there is differential phosphorylation of specific residues in the sMyBP-C paralog within the slow soleus and the fast flexor digitorum brevis muscles early in the lifespan (between the ages of 2 and 14 months) from WT mice and from mice with dystrophy (mdx mouse model) providing sufficient rationale for further investigation of this sarcomeric protein and its paralogs as potential factors contributing to the complex nature of sarcopenia [10, 20]. The gene discussed is MYBPC3; the disease is sarcopenia.