IGFBP3 and neoplasm: As shown in Table 3, the following variables remained independently prognostic: serum IGFBP3 (P = 0.005, HR = 0.468; 95% CI 0.275–0.794), tumor size (P = 0.018, HR = 1.993; 95% CI 1.126–3.526) and TNM stage (P = 0.014, HR = 2.010; 95% CI 1.151–3.510).