Interestingly, the proteasome‐dependent degradation of full‐length AXL (AXL‐FL) has been reported to couple with production of AXL intracellular domain (ICD), and AXL‐ICD could regulate the expression of cancer‐related genes [40], which is believed to be one of the ligand‐independent functions of AXL. This evidence concerns the gene AXL and cancer.