PTK2 and cancer: FAK overexpression and increased phosphorylation levels have also been associated with high histologic grade, lymph node metastasis, and myometrial invasion in uterine cancer [51] and correlate with worse OS (overall survival) in different types of cancers including endometrial cancer (HR = 4.15, 95% CI: 2.83–6.08, P = 0) [51, 52].