Also, [132] recently reported that social memory deficits in a mouse model of AD (Tg2576) were associated with disrupted PNNs around PV+ cells in CA2 and these memory deficits and changes in PNN levels could be prevented by local injection of neuregulin‐1 (NRG‐1) (an important factor for PV cell maturation), suggesting that protecting PV cell integrity in this area may be important for retaining social memory in AD (see also [133], who suggested general targeting of PNNs for the treatment of impaired memory). This evidence concerns the gene NRG1 and Alzheimer disease.