Zn(2+)-dependent phosphorylation of SRSF6 has previously been associated with apoptosis via generation of BIM-S (Hara et al., 2013) and ubiquitin-mediated control of SRSF6 protein levels has been linked to exon skipping in T cell acute lymphoblastic leukemia (Zhou et al., 2020). Here, SRSF6 is linked to acute lymphoblastic leukemia.