In women with normal ovarian function, LH and FSH levels are approximately equal during the early part of the menstrual cycle prior to ovulation, but in women with PCOS, LH levels are higher than FSH levels, almost to a 2:1 ratio even when the levels of both hormones are within the normal physiological range [22,23]. The gene discussed is BRD2; the disease is polycystic ovary syndrome.