We identified two G × G interactions, cg14391855 ×cg23937960 (mapped to RELA × HLA‐G) as well as cg08872738 × cg27077312 (mapped to TUBA1B ×TOMM40), which were significantly and robustly associated with NSCLC survival at both the epigenetic and transcriptional levels. Here, HLA-G is linked to non-small cell lung carcinoma.