The K‐M curve distribution of DFS prognosis‐related genes in the TARGET dataset showed that some overlapped enriched genes, such as Zinc finger protein 720 (ZNF720, also known as KRBOX5) (Fig. 2C), Receptor Accessory Protein 3 (REEP3) (Fig. 2D), cyclin M2 (CNNM2) (Fig. 2E) and Cell Growth Regulator with EF‐Hand Domain 1 (CGREF1) (Fig. 2F), were associated with osteosarcoma prognosis (Table S2). Here, REEP3 is linked to osteosarcoma.