GDF15 and hydrops fetalis: Studies on the longitudinal evolution of GDF-15 (≥3 measurements) and its relation with HF prognosis are limited9–12 and even more so in patients with acute HF.10 Furthermore, a multimarker approach might be necessary to account for the heterogeneity in pathophysiology and has been insufficiently applied in this context.9,10 Thus, the full potency of serially measured GDF-15 remains unclear.