GDF15 and hydrops fetalis: An analysis of 14 serum biomarkers in the Bio-SHiFT study in patients with chronic HF showed a strong association of repeated measurements of GDF-15, NT-proBNP, and ST2 with the composite end point of CV mortality, heart transplantation, left ventricular assisted device and HF hospitalization.9 However, these associations were only analyzed separately in a clinical model and a biomarker-adjusted only model as opposed to our study where we also combined both into 1 single model.