The primary logistic regression showed that AF (OR = 0.227, 95% CI = 0.088–0.585, p = 0.002), hypertension history (OR = 3.261, 95% CI = 1.390–7.647, p = 0.007), hyperdense artery sign (OR = 0.223, 95% CI = 0.084–0.589, p = 0.002), occlusion located at proximal M1 segment (OR = 5.323, 95% CI = 2.234–12.679, p < 0.0001), and M2 segment (OR = 0.074, 95% CI = 0.008–0.677, p = 0.021), and CBS (OR = 1.686, 95% CI = 1.243–2.285, p = 0.001) were independently correlated to ICAS-LVO diagnoses (Table 3). The gene discussed is CBS; the disease is familial isolated congenital asplenia.