Being male [odds ratio (OR) = 1.982, 95% confidence interval (CI) = 1.020–3.851, p = 0.043], hypertension history (OR = 2.450, 95% CI = 1.191–5.038, p = 0.015), smoking personal history (OR = 2.650, 95% CI = 1.414–4.968, p = 0.002), occlusion located at proximal M1 segment (OR = 5.169, 95% CI = 2.722–9.816, p < 0.0001), and CBS levels (OR = 1.381, 95% CI = 1.155–1.652, p < 0.0001), and platelets count (OR = 1.005, 95% CI = 1.001–1.009, p = 0.01) were positively correlated to ICAS-LVO diagnoses. This evidence concerns the gene CBS and familial isolated congenital asplenia.