Ozkan et al. (2015) found that the cell-autonomous deletion of MYH10 leads to specific pathway impairments in dendritic branching development, a structural defect associated with a reduction in the number of functional synapses. In humans, mutations in MYH10 cause a severe CNS phenotype, marked by microcephaly, brain and cerebellar atrophy, and severe intellectual disability (Tuzovic et al., 2013). The gene discussed is MYH10; the disease is Intellectual disability.