HTT and Huntington disease: Therefore, in this study, we performed microarray profiling of hypothalamic samples from two different HD mouse models; the transgenic BACHD mice [bacterial artificial chromosome (BAC)-mediated; full-length mHTT] and wild-type mice with hypothalamus targeted overexpression of N-terminal HTT fragments (wtHTT 18Q; AAV-HTT853-18Q or mHTT 79Q; AAV-HTT853-79Q).