STING1 and neurodegenerative disease: We next assessed the expression of proteins associated with cGAS-STING signaling, a cytosolic DNA sensing pathway involved in initiating a type-I interferon response to genotoxic stress or viral infection which has been shown to be elevated in brain injury and neurodegenerative diseases (Barrett et al., 2021; Decout et al., 2021; Paul et al., 2021).