These findings reveal that mice fed MeDi were better protected against cognitive deficits and AD-related pathologies induced by LPS treatment in the gut and the presence of human APP, including the strong enhancement of full-length APP levels and cleavage of its C-terminal forms, the increased presence of soluble Aβ42, WD-induced hippocampal astrogliosis, and widespread white matter microgliosis, than mice fed WD (Kahn et al., 2012; Ivanova et al., 2020; Wiȩckowska-Gacek et al., 2021). Here, APP is linked to Cognitive impairment.