In addition to metabolic syndrome, which is found to be contemporaneous with the progression of neurodegeneration in AD models, WD strongly accelerates the AD pathological processes through LPS translocation, BBB impairment, intensification of the amyloidogenic APP cleavage path, and chronic activation of glial cells with impaired phagocytic abilities (Ivanova et al., 2020). Here, APP is linked to Alzheimer disease.